Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

C G Brunstein; B A Hirsch; D Hammerschmidt; R C McGlennen; P L Nguyen; C M Verfaillie

doi:10.1038/sj.bmt.1703577

Leukemia in donor cells after allogeneic hematopoietic stem cell transplant

Bone Marrow Transplant. 2002 Jun;29(12):999-1003. doi: 10.1038/sj.bmt.1703577.

Authors

C G Brunstein¹, B A Hirsch, D Hammerschmidt, R C McGlennen, P L Nguyen, C M Verfaillie

Affiliation

¹ Division of Hematology, Oncology and Transplantation, Department of Medicine University of Minnesota, Minneapolis, MN 55455, USA.

PMID: 12098070
DOI: 10.1038/sj.bmt.1703577

Abstract

The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34(+) cells.

Publication types

Case Reports

MeSH terms

Adult
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / pathology
Cytogenetic Analysis
Fatal Outcome
Hematopoietic Stem Cell Transplantation*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / pathology
Leukemia, Lymphocytic, Chronic, B-Cell / therapy*
Leukemia, Myeloid / etiology
Leukemia, Myeloid / genetics*
Leukemia, Myeloid / pathology
Male
Minisatellite Repeats
Myelodysplastic Syndromes / pathology
Myelodysplastic Syndromes / therapy
Neoplasms, Second Primary / etiology
Neoplasms, Second Primary / genetics*
Neoplasms, Second Primary / pathology
Tissue Donors
Transplantation Chimera / genetics
Transplantation, Homologous