Abstract
[reaction: see text] The tricyclic core of phomactin A was synthesized from 6,6-dimethyl-2-cyclohexen-1-one. Key reactions include the addition of a cyclohexenyllithium reagent to an epoxyaldehyde and a regioselective intramolecular epoxide opening to install the oxadecalin core.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Ascomycota / chemistry*
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Epoxy Compounds / chemistry
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Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
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Indicators and Reagents
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Platelet Activating Factor / antagonists & inhibitors*
Substances
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Epoxy Compounds
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Heterocyclic Compounds, 4 or More Rings
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Indicators and Reagents
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Platelet Activating Factor
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phomactin A