Abstract
We evaluated erythrocyte recovery in 121 allogeneic haematopoietic stem cell transplantation (HSCT) recipients. There were 35 major and minor ABO-incompatible transplants, respectively, including 10 bi-directionally ABO-incompatible transplants. The use of peripheral blood stem cells facilitated erythrocyte recovery, regardless of the presence or absence of major ABO-incompatibility, and was associated with a frequent detection of anti-host isohaemagglutin early after minor ABO-incompatible transplantation, which was not associated with clinically relevant haemolysis. The use of a reduced-intensity regimen combining a purine analogue and busulphan did not delay erythrocyte recovery after major ABO-incompatible transplantation, suggesting this regimen had a strong activity against host plasma cell.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ABO Blood-Group System
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Adolescent
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Adult
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Aged
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Bone Marrow Transplantation
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Erythrocyte Count
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Erythrocytes / cytology*
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Female
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Hemagglutinins / analysis
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Hematopoietic Stem Cell Transplantation*
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Humans
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Leukemia / blood
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Leukemia / surgery*
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Leukemia / therapy
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / surgery
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Leukemia, Myeloid, Acute / blood
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Leukemia, Myeloid, Acute / surgery
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Lymphoma, Non-Hodgkin / blood
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Lymphoma, Non-Hodgkin / surgery
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Male
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Middle Aged
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Myelodysplastic Syndromes / blood
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Myelodysplastic Syndromes / surgery
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / surgery
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Time Factors
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Transplantation Conditioning / methods*
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Transplantation, Homologous
Substances
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ABO Blood-Group System
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Hemagglutinins