Abstract
In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenocarcinoma / enzymology*
-
Aged
-
Aged, 80 and over
-
Alkylating Agents / adverse effects
-
Alkylating Agents / pharmacokinetics
-
Cecal Neoplasms / enzymology
-
Colon / enzymology*
-
Female
-
Genetic Variation
-
Humans
-
Intestinal Mucosa / enzymology
-
Male
-
Middle Aged
-
Neoplasm Proteins / analysis*
-
O(6)-Methylguanine-DNA Methyltransferase / analysis*
-
Rectal Neoplasms / enzymology*
-
Rectum / enzymology*
-
Sigmoid Neoplasms / enzymology
Substances
-
Alkylating Agents
-
Neoplasm Proteins
-
O(6)-Methylguanine-DNA Methyltransferase