Abstract
Novel 5,5-fused thiophene lactams are potent inhibitors and acylating agents of HNE and PPE.
MeSH terms
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Alkylating Agents / chemical synthesis
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Animals
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Binding Sites
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Crystallography, X-Ray
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Humans
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Lactams / chemical synthesis*
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Leukocyte Elastase / antagonists & inhibitors
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Mass Spectrometry
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Molecular Conformation
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Pancreatic Elastase / antagonists & inhibitors
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Serine Proteinase Inhibitors / chemical synthesis*
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Swine
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Thiophenes / chemical synthesis*
Substances
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Alkylating Agents
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Lactams
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Serine Proteinase Inhibitors
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Thiophenes
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Pancreatic Elastase
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Leukocyte Elastase