Africa possesses little capacity for influenza surveillance-Senegal and South Africa being the only countries in the WHO African region who regularly pursue active surveillance and characterize influenza isolates. South Africa has three sites-in Cape Town, Durban and the largest in Johannesburg at the National Institute for Virology (NIV). The NIV antigenically and molecularly characterizes influenza viruses isolated from specimens provided by a sentinel network of approximately 50 clinical sites. This information, together with the isolates themselves are supplied to WHO International Influenza Centres in London and Melbourne. In addition, proxy markers of influenza severity such as school absenteeism and doctor/clinic visits are monitored to assess the severity of epidemics. Although, influenza exacts a heavier toll of the illness burden in developing countries already beset with underlying chronic medical conditions and also has a more severe impact on economies largely dependent on single income earners and subsistence farmers, influenza surveillance and vaccination awareness is woefully lacking on the African continent, and this urgently needs to be remedied.