Synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines as potential anti-cancer agents

Ahmed Kamal; N Laxman; G Ramesh; O Srinivas; P Ramulu

doi:10.1016/s0960-894x(02)00324-4

Synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines as potential anti-cancer agents

Bioorg Med Chem Lett. 2002 Aug 5;12(15):1917-9. doi: 10.1016/s0960-894x(02)00324-4.

Authors

Ahmed Kamal¹, N Laxman, G Ramesh, O Srinivas, P Ramulu

Affiliation

¹ Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. [email protected]

PMID: 12113808
DOI: 10.1016/s0960-894x(02)00324-4

Abstract

The design and facile synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines is described. These have been prepared by linking the amines at C-8 position with propane spacer to improve solubility in water, and their in vitro cytotoxicity studies have been carried out.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry
Antineoplastic Agents, Alkylating / chemical synthesis*
Antineoplastic Agents, Alkylating / pharmacology*
Benzodiazepines / chemistry*
Benzodiazepines / pharmacology*
Drug Design
Drug Screening Assays, Antitumor
Humans
Lethal Dose 50
Propane / chemistry
Pyrroles / chemistry*
Pyrroles / pharmacology*
Solubility
Toxicity Tests
Tumor Cells, Cultured

Substances

Amines
Antineoplastic Agents, Alkylating
Pyrroles
Benzodiazepines
Propane