Abstract
We determined whether an antifungal 14-kDa protein trypsin inhibitor isolated from corn is able to cross the blood-brain barrier. We found that it completely crossed the blood-brain barrier by means of a saturable mechanism at a rate of 0.153 microl/g. min, with about 0.082% of the intravenously injected dose being taken up per gram of brain.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Algorithms
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Animals
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacokinetics*
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Blood-Brain Barrier / physiology*
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Brain / metabolism
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Injections, Intravenous
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Mice
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Mice, Inbred ICR
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Molecular Weight
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Trypsin Inhibitors / isolation & purification*
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Trypsin Inhibitors / pharmacokinetics*
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Zea mays / chemistry*
Substances
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Antifungal Agents
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Trypsin Inhibitors