Abstract
Most types of cancer are difficult to eradicate and some, like liver carcinomas, are almost always fatal. Significantly, we report here that direct intraarterial delivery of 3-bromopyruvate (3-BrPA), a potent inhibitorof cell ATP production, to liver-implanted rabbit tumors, inflicts a rapid, lethal blow to most cancer cells therein. Moreover, systemic delivery of 3-BrPA suppresses "metastatic" tumors that arise in the lungs. In both cases, there is no apparent harm to other organs or to the animals. Thus, intraarterial delivery of agents like 3-BrPA directly to the site of the primary tumor, followed by systemic delivery only when necessary, may represent a powerful new strategy for arresting the growth of liver and other cancers while minimizing toxic side effects.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine Triphosphate / antagonists & inhibitors
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Adenosine Triphosphate / biosynthesis
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Animals
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Antineoplastic Agents / administration & dosage*
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Cell Division / drug effects
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Cell Survival / drug effects
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Embolization, Therapeutic
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Injections, Intra-Arterial
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Liver Neoplasms, Experimental / drug therapy*
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Liver Neoplasms, Experimental / metabolism
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Liver Neoplasms, Experimental / pathology
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Liver Neoplasms, Experimental / therapy
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Lung Neoplasms / drug therapy
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Lung Neoplasms / pathology
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Lung Neoplasms / secondary
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Neoplasm Transplantation
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Pyruvates / administration & dosage*
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Pyruvates / adverse effects
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Rabbits
Substances
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Antineoplastic Agents
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Pyruvates
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bromopyruvate
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Adenosine Triphosphate