Abstract
A new method was developed to identify nonpeptidic metalloproteinase inhibitors with novel zinc binding groups. Application of this method to matrix metalloproteinase-9 resulted in the identification of aminomethyl benzimidazole analogue 7a with an IC(50)=13 microM.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / chemistry
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Benzimidazoles / metabolism
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Benzimidazoles / pharmacology*
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Binding Sites
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Drug Design*
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology*
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Inhibitory Concentration 50
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Matrix Metalloproteinase Inhibitors*
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Molecular Structure
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Solubility
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Zinc / metabolism
Substances
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Benzimidazoles
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Enzyme Inhibitors
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Matrix Metalloproteinase Inhibitors
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Zinc