Abstract
Formation of highly organized neocortical structure depends on the production and correct placement of the appropriate number and types of neurons. POU homeodomain proteins Brn-1 and Brn-2 are coexpressed in the developing neocortex, both in the late precursor cells and in the migrating neurons. Here we show that double disruption of both Brn-1 and Brn-2 genes in mice leads to abnormal formation of the neocortex with dramatically reduced production of layer IV-II neurons and defective migration of neurons unable to express mDab1. These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development.
MeSH terms
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Animals
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Biomarkers
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Cell Differentiation
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Cell Lineage
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Embryonic and Fetal Development
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Gene Expression
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Homeodomain Proteins / genetics
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Homeodomain Proteins / physiology*
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Mice
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Mice, Knockout
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Neocortex / cytology*
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Neocortex / embryology
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Nerve Tissue Proteins / genetics
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Neurons / cytology*
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Neurons / metabolism
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Neuropeptides / genetics
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Neuropeptides / physiology*
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POU Domain Factors
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Trans-Activators / genetics
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Trans-Activators / physiology*
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Transcription Factors / genetics
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Transcription Factors / physiology*
Substances
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Biomarkers
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Dab1 protein, mouse
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Homeodomain Proteins
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Nerve Tissue Proteins
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Neuropeptides
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POU Domain Factors
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Trans-Activators
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Transcription Factors
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transcription factor Brn-2
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Pou3f3 protein, mouse