Abstract
Activity-directed fractionation of a phytotoxic extract from Cosmos pringlei led to the isolation of three new compounds, namely, 1'-isovaleroyloxy-4-O-isobutyryleugenol (1), zaluzanin C isobutyrate (2), and zaluzanin C isovalerate (3). In addition, mokko lactone, 1'-isobutiroyloxy-4-O-isobutyryleugenol (4), dehydrocostus lactone (5), costunolide (6), 15-isovaleroyloxycostunolide (7), 15-isobutiroyloxycostunolide (8), 1',2'-epoxy-3',4'-di-isobutyryl-Z-coniferyl alcohol, and 3beta-hydroxy-5alpha-pregn-16-en-20-one were obtained. The structures of the new compounds were established by spectral methods. Compounds 5-7 caused inhibition of radicle growth of seedlings of Amaranthus hypochondriacus.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amaranthus* / drug effects
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Amaranthus* / embryology
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Amaranthus* / growth & development
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Asteraceae / chemistry*
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Asteraceae / metabolism
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Chromatography, High Pressure Liquid
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Inhibitory Concentration 50
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Mexico
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phenylpropionates / chemistry
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Phenylpropionates / isolation & purification*
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Phenylpropionates / pharmacology
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Structure-Activity Relationship
Substances
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1'-isovaleroyloxy-4-O-isobutyryleugenol
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Lactones
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Phenylpropionates
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Sesquiterpenes
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zaluzanin C isobutyrate
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zaluzanin C isovalerate