Abstract
Two new compounds, agonodepsides A (1) and B (2), were isolated from a nonsporulating filamentous fungus, F7524. The compounds were purified via reversed-phase chromatography and their structures determined by spectroscopic methods. Agonodepside A (1) was found to inhibit the mycobacterial InhA enzyme with an IC50 value of 75 microM, while 2 was inactive at 100 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins
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Depsides
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Derris / chemistry
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Fungi / chemistry*
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Hydroxybenzoates / chemistry
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Hydroxybenzoates / isolation & purification*
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Hydroxybenzoates / pharmacology
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Molecular Structure
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / enzymology
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NAD / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Oxidoreductases / drug effects
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Plant Leaves / chemistry
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Plants / chemistry
Substances
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Bacterial Proteins
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Depsides
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Hydroxybenzoates
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agonodepside A
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agonodepside B
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NAD
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Oxidoreductases
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InhA protein, Mycobacterium