Fibroblast growth factors and their receptors in oligodendrocyte development: implications for demyelination and remyelination

Dev Neurosci. 2002;24(1):35-46. doi: 10.1159/000064944.

Abstract

Fibroblast growth factors are a family of broad-spectrum growth factors influencing a plethora of cellular activities. The interaction of at least 23 ligands, 4 receptors and multiple coreceptors provides a dramatic complexity to a signaling system capable of effecting a multitude of responses. This review focuses on the fibroblast growth factors signaling in oligodendrocyte development, function and discusses implications for demyelination/remyelination.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / drug effects
  • Cell Differentiation
  • Cell Lineage
  • Demyelinating Diseases / metabolism*
  • Fibroblast Growth Factor 2 / pharmacology
  • Fibroblast Growth Factors / classification
  • Fibroblast Growth Factors / genetics
  • Fibroblast Growth Factors / physiology*
  • Myelin Proteins / biosynthesis
  • Myelin Proteins / genetics
  • Myelin Sheath / physiology*
  • Nerve Tissue Proteins / physiology*
  • Oligodendroglia / cytology*
  • Oligodendroglia / drug effects
  • Oligodendroglia / metabolism
  • Receptors, Fibroblast Growth Factor / physiology*
  • Signal Transduction / drug effects

Substances

  • Myelin Proteins
  • Nerve Tissue Proteins
  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factor 2
  • Fibroblast Growth Factors