A general method for the formation of aryl-sulfur bonds using copper(I) catalysts

Org Lett. 2002 Aug 8;4(16):2803-6. doi: 10.1021/ol0264105.

Abstract

[reaction: see text] We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 degrees C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Catalysis
  • Copper / chemistry*
  • Sulfur / chemistry*

Substances

  • Sulfur
  • Copper