Effects of an enhanced heart rate reserve on aerobic performance in patients with a heart transplant

Am J Phys Med Rehabil. 2002 Aug;81(8):584-9. doi: 10.1097/00002060-200208000-00005.

Abstract

Objective: The aim of this study was to investigate whether a high-intensity warm-up at the start of a graded, symptom-limited exercise test would enhance heart rate reserve and thus improve the aerobic performance of orthotopic heart transplant patients.

Design: Adrenal and cardiorespiratory responses were compared in 10 orthotopic heart transplant patients who performed two graded, symptom-limited exercise tests on an ergocycle.

Results: At the start of the graded, symptom-limited exercise test, high intensity increased the norepinephrine level more than usual intensity between rest and the third minute of exercise. This higher norepinephrine level was followed by a higher heart rate response from the fourth minute of exercise. Heart rate reserve was enhanced during high-intensity exercise, without any significant change in peak oxygen uptake.

Conclusions: This specific warm-up enhanced heart rate reserve during a graded, symptom-limited exercise test on an ergocycle. Mechanisms more important than limited heart rate reserve are involved in the limitation of exercise tolerance in orthotopic heart transplant patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic alpha-Agonists / blood
  • Exercise / physiology*
  • Exercise Test / methods*
  • Exercise Tolerance / physiology
  • Heart Rate / physiology*
  • Heart Transplantation / rehabilitation*
  • Humans
  • Male
  • Middle Aged
  • Norepinephrine / blood
  • Oxygen Consumption / physiology
  • Task Performance and Analysis
  • Treatment Outcome

Substances

  • Adrenergic alpha-Agonists
  • Norepinephrine