Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia

Christophe Aucan; Andrew J Walley; Brian M Greenwood; Adrian V S Hill

doi:10.1016/s0035-9203(02)90114-8

Haptoglobin genotypes are not associated with resistance to severe malaria in The Gambia

Trans R Soc Trop Med Hyg. 2002 May-Jun;96(3):327-8. doi: 10.1016/s0035-9203(02)90114-8.

Authors

Christophe Aucan¹, Andrew J Walley, Brian M Greenwood, Adrian V S Hill

Affiliation

¹ Wellcome Trust Centre For Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK. [email protected]

PMID: 12174790
DOI: 10.1016/s0035-9203(02)90114-8

Abstract

The influence of haptoglobin polymorphisms on severe malaria occurrence was assessed in 1183 individuals from The Gambia. No significant association was found between severe malaria and either haptoglobin genotypes or phenotypes. The advantages of using a deoxyribonucleic acid-based haptoglobin typing method are discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Gambia
Gene Frequency
Genetic Predisposition to Disease
Genotype
Haptoglobins / genetics*
Humans
Immunity, Innate / genetics
Malaria, Falciparum / genetics*
Malaria, Falciparum / immunology
Polymorphism, Genetic*

Substances

Haptoglobins