Abstract
Double-stranded RNA (dsRNA) viruses conceal their genome from the host to avoid triggering unfavorable cellular responses. The crystal structure of the core of one such virus, bluetongue virus, reveals an outer surface festooned with dsRNA. This may represent a deliberate strategy to sequester dsRNA released from damaged particles to prevent host cell shutoff.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites
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Bluetongue virus / metabolism*
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Crystallography, X-Ray
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Humans
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Models, Molecular
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Protein Conformation
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RNA, Double-Stranded / chemistry
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RNA, Double-Stranded / metabolism*
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RNA, Viral / chemistry
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RNA, Viral / metabolism*
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Viral Core Proteins / chemistry
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Viral Core Proteins / metabolism*
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X-Ray Diffraction
Substances
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RNA, Double-Stranded
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RNA, Viral
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Viral Core Proteins
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VP7 protein, orbivirus