Abstract
Three new sterols, 5alpha,6alpha-epoxy-24R-ethylcholest-8(14)-en-3beta,7alpha-diol (1), 5alpha,6alpha-epoxy-24R-ethylcholest-8-en-3beta,7alpha-diol (2), and 3beta-hydroxy-24R-ethylcholesta-5,8-dien-7-one (3), have been isolated from the marine sponge Polymastia tenax, collected in the Colombian Caribbean, and their structures established on the basis of extensive NMR and MS studies. Compounds 1 and 2 showed antiproliferative activity toward A-549, HT-29, H-116, MS-1, and PC-3 tumor cells in the range 0.5-10 microg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Caribbean Region
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Chromatography, High Pressure Liquid
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Colombia
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Colonic Neoplasms
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Lung Neoplasms
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Male
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Mass Spectrometry
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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Prostatic Neoplasms
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Stereoisomerism
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Sterols / chemistry
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Sterols / isolation & purification*
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Sterols / pharmacology
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Tumor Cells, Cultured / drug effects
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Tumor Cells, Cultured / enzymology
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Tumor Cells, Cultured / metabolism
Substances
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3beta-hydroxy-24R-ethylcholesta-5,8-dien-7-one
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5alpha,6alpha-epoxy-24R-ethylcholest-8(14)-en-3beta,7alpha-diol
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5alpha,6alpha-epoxy-24R-ethylcholest-8-en-3beta,7alpha-diol
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Sterols