Abstract
The sesterterpene constituents of two Indo-Pacific sponges were investigated and rapidly characterized using aggressive dereplication methods along with gradient 1D NMR techniques. Lendenfeldia frondosa yielded three sesterterpenes: 12beta,16beta,22-trihydroxy-24alpha-methylscalar-25beta,24alpha-olide (1), the 24 epimer of a known compound; 12beta,22-dihydroxy-24-methylscalar-17-en-24,25-olide (2), a known compound; and 22-hydroxy-24-methylsedn-16-en-24-one-12beta,25beta-olide (3), a new compound. A Hyrtios sp. sponge yielded known 12alpha-acetoxy-16beta-hydroxyscalarolbutenolide (5).
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chromatography, High Pressure Liquid
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular / methods*
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Papua New Guinea
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Porifera / chemistry*
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Stereoisomerism
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Terpenes / chemistry*
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Terpenes / isolation & purification
Substances
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12alpha-acetoxy-16beta-hydroxyscalarolbutenolide
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12beta,16beta,22-trihydroxy-24alpha-methylscalar-25beta,24alpha-olide
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12beta,22-dihydroxy-24-methylscalar-17-en-24,25-olide
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22-hydroxy-24-methylsedn-16-en-24-one-12beta,25beta-olide
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Terpenes