Abstract
In this longitudinal study of 77 patients with mild cognitive impairment (MCI), the authors analyzed whether levels of tau protein phosphorylated at threonine 231 (p-tau(231)) in CSF correlate with progression of cognitive decline. High CSF p-tau(231) levels at baseline, but not total tau protein levels, correlated with cognitive decline and conversion from MCI to AD. Independently, old age and APOE-epsilon 4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Age Factors
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Aged
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Aged, 80 and over
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Alzheimer Disease / cerebrospinal fluid
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Alzheimer Disease / complications
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Alzheimer Disease / diagnosis
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Apolipoprotein E4
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Apolipoproteins E / genetics
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Biomarkers / cerebrospinal fluid
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Cognition Disorders / cerebrospinal fluid*
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Cognition Disorders / complications
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Cognition Disorders / diagnosis*
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Cognition Disorders / genetics
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Disease Progression
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Female
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Follow-Up Studies
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Humans
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Longitudinal Studies
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Male
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Middle Aged
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Neuropsychological Tests
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Phosphorylation
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Predictive Value of Tests
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Regression Analysis
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Risk Factors
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Threonine / metabolism
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tau Proteins / cerebrospinal fluid*
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tau Proteins / metabolism*
Substances
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Apolipoprotein E4
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Apolipoproteins E
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Biomarkers
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tau Proteins
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Threonine