Insights into antigen processing gained by direct analysis of the naturally processed class I MHC associated peptide repertoire

Mol Immunol. 2002 Oct;39(3-4):127-37. doi: 10.1016/s0161-5890(02)00096-2.

Abstract

MHC class I molecules are responsible for the presentation of antigenic peptides to CD8+ T lymphocytes. Based on their relatively promiscuous binding of peptides, these molecules display information derived from a large fraction of proteins that are made inside the cell. This review describes our characterization of the peptides comprising this repertoire, with particular attention given to their complexity and quantities, their post-translational modification, and the pathways leading to their expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigen Presentation*
  • Cysteine Endopeptidases / physiology
  • Endoplasmic Reticulum / metabolism
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Minor Histocompatibility Antigens / metabolism
  • Molecular Sequence Data
  • Monophenol Monooxygenase / metabolism
  • Multienzyme Complexes / physiology
  • Peptides / metabolism*
  • Proteasome Endopeptidase Complex
  • Protein Processing, Post-Translational

Substances

  • Histocompatibility Antigens Class I
  • Minor Histocompatibility Antigens
  • Multienzyme Complexes
  • Peptides
  • Monophenol Monooxygenase
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex