Abstract
Ceramidated GLA-60 derivatives 11 and 11' were synthesized from 1 via glycosidation of ceramide derivative 12 as a glycosyl acceptor with GLA-60 derivative 5 as a glycosyl donor, and successive conversion. Compound 11' showed only weak LPS-antagonistic activity without showing any LPS-agonistic activity.
MeSH terms
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Adjuvants, Immunologic / chemical synthesis*
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Adjuvants, Immunologic / chemistry
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Ceramides / chemistry*
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Lipid A / analogs & derivatives*
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Lipid A / chemical synthesis*
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Lipid A / chemistry
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Molecular Structure
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Spectrophotometry, Infrared
Substances
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Adjuvants, Immunologic
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Ceramides
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Lipid A
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GLA 60