Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis

Jennifer LeCouter; Rui Lin; Napoleone Ferrara

doi:10.1038/nm0902-913

Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis

Nat Med. 2002 Sep;8(9):913-7. doi: 10.1038/nm0902-913.

Authors

Jennifer LeCouter¹, Rui Lin, Napoleone Ferrara

Affiliation

¹ Department of Molecular Oncology, Genentech, Inc., South San Francisco, California, USA.

PMID: 12205443
DOI: 10.1038/nm0902-913

Abstract

The diversity in growth and morphological characteristics among endothelial cells in different normal tissues and tumors has been long recognized. Yet there has been no clear molecular explanation for such diversity at the level of vascular endothelial growth factor A (VEGF-A) and other established regulators of angiogenesis that are expressed widely and show little tissue selectivity in their angiogenic properties. Endocrine gland-derived VEGF represents the first example of a tissue-specific angiogenic factor, likely to be followed by others.

Publication types

Review

MeSH terms

Animals
Endocrine Glands / metabolism
Endothelial Growth Factors / physiology
Gastrointestinal Hormones*
Humans
Lymphokines / physiology
Mitogens / physiology*
Neovascularization, Physiologic*
Organ Specificity
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
Vascular Endothelial Growth Factors

Substances

Endothelial Growth Factors
Gastrointestinal Hormones
Lymphokines
Mitogens
PROK1 protein, human
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor, Endocrine-Gland-Derived
Vascular Endothelial Growth Factors