Objective: To observe the effects of Tongfugushen(TFGS) on adenine-induced chronic renal failure in rats.
Methods: The model of chronic renal failure was made by feeding rats with food containing 0.5% adenine. Two weeks later, along with the above food, the treated group was administered the Chinese patent medicine TFGS, and the control group was given NS. Blood tests including urea nitrogen(BUN), serum creatinine(Scr), red blood cell(RBC), hemoglobin (Hb), hematocrit(HCT) and renal pathological tests were performed at the end of the fourth week.
Result: In the TFGS treated group, the mean levels of BUN and Scr were lower and the mean values of RBC, Hb and HCT were higher than those in the control group, and the deposited crystals of adenine metabolite and the proliferation of fibroid tissue in kidney were decreased.
Conclusion: TFGS is helpful in improving the symptoms of chronic renal failure in rats.