No association between the neuronal nitric oxide synthase gene polymorphism and Alzheimer Disease

Am J Med Genet. 2002 Aug 8;114(6):687-8. doi: 10.1002/ajmg.10670.

Abstract

Nitric oxide synthase (NOS) has been implicated in the pathogenesis of Alzheimer disease (AD). To examine the role of the neuronal NOS (nNOS) gene in AD, patients (n = 139) and control subjects (n = 101) were genotyped for the nNOS dinucleotide polymorphism. No association was demonstrated for AD and this particular nNOS polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / enzymology*
  • Alzheimer Disease / genetics
  • Alzheimer Disease / pathology
  • Case-Control Studies
  • Dinucleotide Repeats
  • Female
  • Gene Frequency
  • Humans
  • Male
  • Neurons / enzymology
  • Neurons / pathology
  • Nitric Oxide Synthase / genetics*
  • Nitric Oxide Synthase Type I
  • Polymorphism, Genetic*

Substances

  • NOS1 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type I