[Effect of sodium ferulate on proliferation of rabbit aortic smooth muscle cells induced by oxidized LDL]

Zhongguo Zhong Yao Za Zhi. 1999 Jun;24(6):365-6, 384.
[Article in Chinese]

Abstract

Objective: To investigate the effect of sodium ferulate on the proliferation and lipid peroxidation of aortic smooth muscle cells(SMC).

Method: Using experimental models of proliferation of cultured rabbit aortic SMC induced by oxidized-low density lipoprotein, the level of lipoperoxide(LPO) was determined by thiobarbituric acid reactive substance(TBARS) method and 3H-thymidine(3H-TdR) incorporation was used to observe DNA synthesis.

Results: SF markedly reduced the increase of medium LPO and inhibited the 3H-TdR incorporation in a dose-dependent manner.

Conclusion: SF can inhibit the proliferation of SMC. The inhibitory effect may be related to the inhibition of lipid peroxidation.

Publication types

  • English Abstract

MeSH terms

  • Angelica sinensis / chemistry
  • Animals
  • Aorta, Thoracic
  • Cell Division / drug effects
  • Cells, Cultured
  • Coumaric Acids / isolation & purification
  • Coumaric Acids / pharmacology*
  • DNA / biosynthesis
  • Female
  • Lipid Peroxides / metabolism*
  • Lipoproteins, LDL / pharmacology
  • Male
  • Muscle, Smooth, Vascular / cytology*
  • Plants, Medicinal / chemistry
  • Rabbits

Substances

  • Coumaric Acids
  • Lipid Peroxides
  • Lipoproteins, LDL
  • oxidized low density lipoprotein
  • DNA
  • ferulic acid