Abstract
Readily accessible, novel, and potent anti-malarial compounds have been developed. Optimization of the initial lead structure resulted in derivatives with IC50 values from 7 to 35 nM against chloroquine-sensitive and 70-350 nM against chloroquine-resistant strains of Plasmodium falciparum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Animals
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Antimalarials / chemical synthesis*
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Antimalarials / pharmacology*
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Cells, Cultured
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Chloroquine / pharmacology
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Drug Resistance
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Plasmodium falciparum / drug effects*
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Structure-Activity Relationship
Substances
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Antimalarials
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Indicators and Reagents
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Chloroquine