Abstract
(5-Azidonaphthalene-1-sulfonamidoethyl)-5-O-(alpha-arabinofuranosyl)-alpha-D-arabinofuranoside 1 was synthesized as a photoaffinity probe for the determination of arabinosyl transferase activity and for the identification of binding and functional sites in Mycobacterium tuberculosis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antitubercular Agents / pharmacology
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Disaccharides / chemical synthesis*
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Ethambutol / pharmacology
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Kinetics
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Magnetic Resonance Spectroscopy
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / enzymology*
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Pentosyltransferases / metabolism*
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Photoaffinity Labels / chemical synthesis*
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Spectrometry, Mass, Fast Atom Bombardment
Substances
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(5-azidonaphthalene-1-sulfonamidoethyl)-5-O-(arabinofuranosyl)-arabinofuranoside
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Antitubercular Agents
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Disaccharides
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Photoaffinity Labels
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Ethambutol
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Pentosyltransferases
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arabinosyltransferase