Abstract
A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group.
MeSH terms
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Chemical Phenomena
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Chemistry, Physical
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Indicators and Reagents
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Nitriles / chemical synthesis*
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Nitriles / pharmacology*
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Quinolines / chemical synthesis*
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Quinolines / pharmacology*
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Solubility
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Structure-Activity Relationship
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src-Family Kinases / antagonists & inhibitors*
Substances
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Enzyme Inhibitors
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Indicators and Reagents
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Nitriles
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Quinolines
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src-Family Kinases