Associative pullulan gels and their interaction with biological active substances

J Control Release. 2002 Sep 18;83(1):41-51. doi: 10.1016/s0168-3659(02)00169-4.

Abstract

This paper studies the synthesis and properties of anionic and/or amphiphilic pullulan microparticles crosslinked with epichlorohydrine or with sodium trimethaphosphate. The polysaccharide gels were physicochemically characterized and their interaction with enzymes (lysozyme) was studied with the aim to appreciate the performances for separation/purification/immobilization of the enzymes or controlled release drug systems.

Publication types

  • Comparative Study

MeSH terms

  • Cross-Linking Reagents / chemistry
  • Cross-Linking Reagents / pharmacokinetics
  • Delayed-Action Preparations / chemistry
  • Delayed-Action Preparations / pharmacokinetics
  • Gels
  • Glucans / chemistry
  • Glucans / pharmacokinetics*
  • Microspheres
  • Muramidase / chemistry
  • Muramidase / pharmacokinetics*

Substances

  • Cross-Linking Reagents
  • Delayed-Action Preparations
  • Gels
  • Glucans
  • pullulan
  • Muramidase