Abstract
A 26-year-old male with acute lymphoblastic leukemia (ALL) in its second complete remission received an unrelated bone marrow transplantation (UBMT) following cyclophosphamide plus total body irradiation conditioning. The patient relapsed 7 months after the BMT. He received a second UBMT from a different donor 15 months after the initial UBMT. Conditioning for the second UBMT consisted of busulphan, melphalan, and anti-thymocyte globulin. The regimen was well tolerated, and engraftment was achieved. Both acute and chronic graft-versus-host diseases occurred but were successfully controlled with immunosuppressive drugs. He is alive and disease-free 29 months after the second UBMT. This is the first report of a successful second UBMT for ALL that had relapsed after the first UBMT and for which a different donor was used.
Copyright 2002 Wiley-Liss, Inc.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Asparaginase / administration & dosage
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Azathioprine / therapeutic use
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Bone Marrow Transplantation* / adverse effects
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Cyclophosphamide / administration & dosage
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Daunorubicin / administration & dosage
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Drug Therapy, Combination
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Female
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Graft vs Host Disease / drug therapy
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Graft vs Host Disease / etiology
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Humans
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Immunosuppressive Agents / therapeutic use
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Living Donors*
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Male
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Methotrexate / therapeutic use
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
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Prednisolone / administration & dosage
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Prednisolone / therapeutic use
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Recurrence
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Remission Induction
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Tacrolimus / therapeutic use
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Transplantation Conditioning
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Transplantation, Homologous* / adverse effects
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Vincristine / administration & dosage
Substances
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Immunosuppressive Agents
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Vincristine
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Cyclophosphamide
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Prednisolone
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Asparaginase
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Azathioprine
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Tacrolimus
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Methotrexate
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Daunorubicin