Since its introduction a few years ago, multidetector row CT (MDCT) has become a widely used diagnostic procedure and has been proven to be a valuable tool for various indications. A major issue using this new modality is the inherent risk of applying increased radiation exposure, when compared to single-slice CT or other imaging modalities.However, MDCT offers some valuable options to save radiation exposure, such as choosing optimized exposure parameters or its superior dose efficiency in comparison to single-slice CT. Multi-phasic examinations should be restricted to indications where definitely necessary. Modern scanners offer intelligent tools for further reduction of radiation dose, such as ECG- or bodyshape-based realtime dose modulation. A new field of applications is the low-dose CT for early detection of diseases. While acquiring thin slices with high spatial resolution, the dose can be reduced to similar values as in conventional radiography, especially when examining under high-contrast conditions. Using all these various options available, radiation exposure can sometimes even be lower than using a conventional single-slice helical CT.