Abstract
Two 4-imidazolylflavans were synthesized and their relative stereochemistry was established by 1H and 13C NMR data. These compounds were tested for their activity to inhibit aromatase. It was observed that the introduction of an imidazolyl group at carbon 4 on flavan nucleus led to potent molecules.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aromatase / chemistry
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Aromatase Inhibitors*
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Female
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Flavonoids / chemical synthesis*
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Flavonoids / pharmacology*
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Humans
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology*
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Placenta / enzymology
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Pregnancy
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Protons
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Aromatase Inhibitors
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Enzyme Inhibitors
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Flavonoids
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Imidazoles
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Protons
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Aromatase