Abstract
A series of substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles has been prepared as Src kinase inhibitors. Optimal activity is observed with compounds that have basic amines attached via the para position of the 7-phenyl ring, and a hydrogen atom at the C-6 position. The best compounds are low nanomolar inhibitors of Src kinase, and have potent activity against Src-transformed fibroblast cells.
MeSH terms
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Indicators and Reagents
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Nitriles / chemical synthesis*
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Nitriles / pharmacology*
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Quinolines / chemical synthesis*
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Quinolines / pharmacology*
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Structure-Activity Relationship
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src-Family Kinases / antagonists & inhibitors*
Substances
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Enzyme Inhibitors
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Indicators and Reagents
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Nitriles
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Quinolines
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src-Family Kinases