Abstract
A mimetic of the A83586C cyclodepsipeptide has been synthesised via a three-segment coupling protocol involving dipeptides 9, 8 and 7; in contrast to our previous synthesis of A83586C, where the HATU-mediated macrolactamisation proceeded in 25% yield, the corresponding macro-lactamisation of seco-amino acid 18 occurred in ca. 78% yield.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry*
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Depsipeptides*
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Dipeptides / chemistry
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Molecular Structure
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Peptides*
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Proline / chemistry*
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Depsipeptides
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Dipeptides
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Peptides
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A 83586C
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Proline