Abstract
Two patients with amiodarone-induced pulmonary toxicity (APT) showed abnormally increased serum SP-D concentrations, although their KL-6 level was within the normal range. In a 59-year-old man with ischemic heart disease, APT progressed rapidly and required steroid pulse therapy. During the clinical course, SP-D was as high as 375 ng/ml, although the KL-6 level was only 289 U/ml. In a 58-year-old man treated for dilated cardiomyopathy, SP-D increased to 289 ng/ml, while KL-6 remained at less than 500 U/ml. These cases indicate that SP-D is a useful and early diagnostic marker for APT even when KL-6 is not elevated.
MeSH terms
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Amiodarone / adverse effects*
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Anti-Arrhythmia Agents / adverse effects*
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Antigens / blood
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Antigens, Neoplasm
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Biomarkers / blood*
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Glucocorticoids / therapeutic use
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Glycoproteins / blood
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Humans
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Lung / diagnostic imaging
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Lung / drug effects*
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Lung Diseases, Interstitial / blood
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Lung Diseases, Interstitial / chemically induced*
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Lung Diseases, Interstitial / therapy
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Male
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Methylprednisolone / therapeutic use
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Middle Aged
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Mucin-1
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Mucins
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Pulmonary Surfactant-Associated Protein D / blood*
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Pulmonary Surfactants / blood*
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Radiography, Thoracic
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Tomography, X-Ray Computed
Substances
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Anti-Arrhythmia Agents
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Antigens
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Antigens, Neoplasm
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Biomarkers
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Glucocorticoids
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Glycoproteins
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MUC1 protein, human
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Mucin-1
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Mucins
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Pulmonary Surfactant-Associated Protein D
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Pulmonary Surfactants
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Amiodarone
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Methylprednisolone