Family of the green fluorescent protein: journey to the end of the rainbow

Bioessays. 2002 Oct;24(10):953-9. doi: 10.1002/bies.10154.

Abstract

Members of the family of the Green Fluorescent Protein (GFP) are the only known type of natural pigments that are essentially encoded by a single gene, since both the substrate for pigment biosynthesis and the necessary catalytic moieties are provided within a single polypeptide chain. In sharp contrast to the state of knowledge just three years ago when GFP was the only known protein of its kind, a whole family of related proteins, exhibiting striking diversity of features have now been identified. This provides new possibilities for a variety of studies ranging from applied biotechnology to evolutionary ecology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biotechnology / methods
  • Catalysis
  • Green Fluorescent Proteins
  • Luminescent Proteins / chemistry*
  • Luminescent Proteins / classification*
  • Models, Chemical
  • Models, Genetic
  • Models, Molecular
  • Phylogeny
  • Rats
  • Scyphozoa

Substances

  • Luminescent Proteins
  • Green Fluorescent Proteins