Antiplasmodial compounds from Cochlospermum tinctorium

J Nat Prod. 2002 Sep;65(9):1325-7. doi: 10.1021/np020008h.

Abstract

Fractionation of an ethanol extract of roots of Cochlospermum tinctorium afforded five compounds: 3-O-E-p-coumaroylalphitolic acid (1), cochloxanthin (2), dihydrocochloxanthin (3), alphitolic acid (4), and 1-hydroxytetradecan-3-one (5). This is the first example of a 1-hydroxyalkan-3-one obtained from plant material after gentle workup. The antiplasmodial activities of the compounds were determined, and the IC(50) value of 3-O-E-p-coumaroylalphitolic acid was 2.3 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Bixaceae / chemistry*
  • Burkina Faso
  • Chromatography, Thin Layer
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Inhibitory Concentration 50
  • Ketones / chemistry
  • Ketones / isolation & purification*
  • Ketones / pharmacology
  • Lymphocytes / drug effects*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal / chemistry*
  • Plasmodium falciparum / drug effects*
  • Rhizome / chemistry
  • Stereoisomerism

Substances

  • Antimalarials
  • Ketones