Abstract
Fractionation of an ethanol extract of roots of Cochlospermum tinctorium afforded five compounds: 3-O-E-p-coumaroylalphitolic acid (1), cochloxanthin (2), dihydrocochloxanthin (3), alphitolic acid (4), and 1-hydroxytetradecan-3-one (5). This is the first example of a 1-hydroxyalkan-3-one obtained from plant material after gentle workup. The antiplasmodial activities of the compounds were determined, and the IC(50) value of 3-O-E-p-coumaroylalphitolic acid was 2.3 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology
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Bixaceae / chemistry*
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Burkina Faso
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Chromatography, Thin Layer
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Gas Chromatography-Mass Spectrometry
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Humans
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Inhibitory Concentration 50
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Ketones / chemistry
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Ketones / isolation & purification*
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Ketones / pharmacology
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Lymphocytes / drug effects*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Plasmodium falciparum / drug effects*
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Rhizome / chemistry
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Stereoisomerism