Imipenem-EDTA disk method for differentiation of metallo-beta-lactamase-producing clinical isolates of Pseudomonas spp. and Acinetobacter spp

J Clin Microbiol. 2002 Oct;40(10):3798-801. doi: 10.1128/JCM.40.10.3798-3801.2002.

Abstract

Rapid detection of metallo-beta-lactamase (MBL)-producing gram-negative bacilli is necessary to prevent their dissemination. The method using a disk with imipenem plus 750 micro g of EDTA differentiated all MBL-producing pseudomonads, and the sensitivity and specificity for acinetobacters were 95.7 and 91.0%, respectively. The imipenem-EDTA disks were stable for 12 and 16 weeks at 4 and -20 degrees C, respectively.

MeSH terms

  • Acinetobacter / enzymology*
  • Acinetobacter / isolation & purification
  • Drug Resistance / physiology
  • Edetic Acid / chemistry
  • Humans
  • Imipenem / metabolism*
  • Pseudomonas / enzymology*
  • Pseudomonas / isolation & purification
  • Reagent Kits, Diagnostic
  • Sensitivity and Specificity
  • beta-Lactamases / metabolism*

Substances

  • Reagent Kits, Diagnostic
  • Imipenem
  • Edetic Acid
  • beta-Lactamases