Abstract
A new, mild and high yielding synthesis of phosphoramidates is described: potassium salts of carboxylic acids are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNH-P(O)(OEt)2 in situ--the methodology is especially suited to acid sensitive systems featuring BOC, tBu or acetal protecting groups.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Amides / pharmacology
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Aspartate-Semialdehyde Dehydrogenase / antagonists & inhibitors*
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Aspartate-Semialdehyde Dehydrogenase / chemistry
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Bacterial Proteins / antagonists & inhibitors
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Bacterial Proteins / metabolism
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Binding Sites
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Models, Molecular
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Phosphoric Acids / chemical synthesis*
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Phosphoric Acids / pharmacology
Substances
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Amides
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Bacterial Proteins
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Enzyme Inhibitors
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Phosphoric Acids
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phosphoramidic acid
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Aspartate-Semialdehyde Dehydrogenase