Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians

V S Farook; C Bogardus; M Prochazka

doi:10.1016/s1096-7192(02)00127-0

Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians

Mol Genet Metab. 2002 Sep-Oct;77(1-2):189-93. doi: 10.1016/s1096-7192(02)00127-0.

Authors

V S Farook¹, C Bogardus, M Prochazka

Affiliation

¹ Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA. [email protected]

PMID: 12359146
DOI: 10.1016/s1096-7192(02)00127-0

Abstract

Several diseases including type 2 diabetes mellitus (T2DM) are associated with abnormal O-glycosylation of proteins. beta-O-linked N-acetylglucosaminidase (O-GlcNAcase) encoded by MGEA5 on 10g24.1-q24.3 removes N-acetylglucosamine (O-GlcNAc), and we investigated this locus in Pima Indians who have the world's highest prevalence of T2DM. We detected two variants but there was no association with parameters of insulin resistance or diabetes in approximately 1300 Pimas. We conclude that mutations in MGEA5 are unlikely to contribute to T2DM in this population.

MeSH terms

Acetylglucosaminidase / genetics*
Alleles
Arizona
Base Sequence
Case-Control Studies
Chromosomes, Human, Pair 10 / genetics
DNA Primers / genetics
Diabetes Mellitus, Type 2 / enzymology*
Diabetes Mellitus, Type 2 / etiology
Diabetes Mellitus, Type 2 / genetics*
Gene Frequency
Histone Acetyltransferases
Humans
Indians, North American / genetics*
Models, Biological
Multienzyme Complexes
Polymorphism, Single Nucleotide
beta-N-Acetylhexosaminidases

Substances

DNA Primers
Multienzyme Complexes
Histone Acetyltransferases
hexosaminidase C
Acetylglucosaminidase
beta-N-Acetylhexosaminidases