Abstract
Antimicrobial susceptibility was determined for 150 Haemophilus influenzae isolates obtained during population-based surveillance for meningitis in Salvador, Brazil. Ten (6.7%) isolates were resistant to ampicillin and chloramphenicol. Of these, two isolates, a beta-lactamase and non-beta-lactamase producer, were resistant to amoxacillin-clavulinic acid. These findings indicate that present antibiotic regimens in Brazil may not be appropriate for the treatment of H. influenzae meningitis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amoxicillin-Potassium Clavulanate Combination / pharmacology
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Amoxicillin-Potassium Clavulanate Combination / therapeutic use
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Brazil / epidemiology
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Cost-Benefit Analysis
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Drug Resistance, Bacterial
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Drug Resistance, Multiple, Bacterial
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Drug Therapy, Combination / pharmacology
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Drug Therapy, Combination / therapeutic use
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Haemophilus Vaccines / economics
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Haemophilus Vaccines / therapeutic use
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Haemophilus influenzae / drug effects*
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Haemophilus influenzae / enzymology
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Humans
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Meningitis, Haemophilus / epidemiology
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Meningitis, Haemophilus / microbiology*
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Meningitis, Haemophilus / prevention & control
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Microbial Sensitivity Tests
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Population Surveillance
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beta-Lactamases / metabolism
Substances
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Haemophilus Vaccines
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Amoxicillin-Potassium Clavulanate Combination
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beta-Lactamases