Pimarane diterpene from Viguiera arenaria (Asteraceae) inhibit rat carotid contraction

Fitoterapia. 2002 Oct;73(6):484-9. doi: 10.1016/s0367-326x(02)00170-3.

Abstract

ent-Pimara-8(14),15-dien-19-oic acid (PA) isolated from Viguiera arenaria (Asteraceae; Heliantheae) inhibited rat carotid rings contraction induced by phenylephrine (10(-8) mol/l) or potassium chloride (45 mmol/l) at concentration ranging from 5 to 20 microg/ml. This inhibitory effect was not reversible after the removal of this compound from the medium bath.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Asteraceae*
  • Carotid Arteries / drug effects*
  • Diterpenes / administration & dosage
  • Diterpenes / pharmacology*
  • Dose-Response Relationship, Drug
  • Male
  • Muscle Contraction / drug effects*
  • Muscle, Smooth, Vascular / drug effects
  • Phenylephrine
  • Phytotherapy*
  • Potassium Chloride
  • Rats
  • Rats, Wistar
  • Vasoconstrictor Agents / administration & dosage
  • Vasoconstrictor Agents / pharmacology*

Substances

  • Diterpenes
  • Vasoconstrictor Agents
  • Phenylephrine
  • Potassium Chloride
  • pimaric acid