Upward bias in estimation of genetic effects

Am J Hum Genet. 2002 Nov;71(5):1183-8. doi: 10.1086/343819. Epub 2002 Oct 17.

Abstract

Because of the large number of tests for linkage that are performed in genome scans, the naive estimator of the size of a genetic effect in cases of borderline significance can be inflated and lead to unrealistic expectations for successful replication. As a remedy, this report proposes lower confidence limits that account for the multiple comparisons of the genome scan.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bias*
  • Confidence Intervals*
  • Genetic Linkage
  • Genetic Markers
  • Genetic Techniques
  • Monte Carlo Method
  • Quantitative Trait Loci*
  • Quantitative Trait, Heritable*

Substances

  • Genetic Markers