Abstract
Extracellular signals are transduced into cells through mitogen-activated protein kinases (MAPKs), which are activated by their upstream kinases. Recently, families of scaffolding proteins have been identified to tether specific combinations of these kinases along specific signaling pathways. Here we describe a protein, JLP (c-Jun NH2-terminal kinase-associated leucine zipper protein), which acts as a scaffolding protein to bring together Max and c-Myc along with JNK (c-Jun NH2-terminal kinase) and p38MAPK, as well as their upstream kinases MKK4 (MAPK kinase 4) and MEKK3 (MAPK kinase kinase 3). Thus, JLP defines a family of scaffolding proteins that bring MAPKs and their target transcription factors together for the execution of specific signaling pathways.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3T3 Cells
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Adaptor Proteins, Signal Transducing*
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Amino Acid Sequence
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Animals
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Basic-Leucine Zipper Transcription Factors
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Binding Sites
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COS Cells
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Chlorocebus aethiops
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Dimerization
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Helix-Loop-Helix Motifs*
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Humans
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JNK Mitogen-Activated Protein Kinases
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Leucine Zippers*
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MAP Kinase Kinase 4*
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MAP Kinase Kinase Kinase 3
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MAP Kinase Kinase Kinases / metabolism
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MAP Kinase Signaling System*
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Mice
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Mitogen-Activated Protein Kinase Kinases / metabolism
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Mitogen-Activated Protein Kinases / metabolism*
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Molecular Sequence Data
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Proteins / genetics
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Proteins / metabolism*
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Proto-Oncogene Proteins c-myc / metabolism
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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p38 Mitogen-Activated Protein Kinases
Substances
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Adaptor Proteins, Signal Transducing
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Basic-Leucine Zipper Transcription Factors
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Carrier Proteins
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DNA-Binding Proteins
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MAX protein, human
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Myc associated factor X
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Proteins
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Proto-Oncogene Proteins c-myc
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Recombinant Fusion Proteins
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Spag9 protein, mouse
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Transcription Factors
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Max protein, mouse
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JNK Mitogen-Activated Protein Kinases
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Mitogen-Activated Protein Kinases
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p38 Mitogen-Activated Protein Kinases
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MAP Kinase Kinase Kinase 3
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MAP Kinase Kinase Kinases
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MAP3K3 protein, human
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Map3k3 protein, mouse
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MAP Kinase Kinase 4
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MAP2K4 protein, human
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Map2k4 protein, mouse
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Mitogen-Activated Protein Kinase Kinases
Associated data
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GENBANK/AF327451
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GENBANK/AF327452