[Clone of M2 autoantigens from human sources and evaluation of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis]

Xiaohua Jiang; Renqian Zhong; Xiaoqing Tu; Wenwen Li; Xiantao Kong

[Clone of M2 autoantigens from human sources and evaluation of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis]

Zhonghua Gan Zang Bing Za Zhi. 2002 Oct;10(5):341-3.

[Article in Chinese]

Authors

Xiaohua Jiang¹, Renqian Zhong, Xiaoqing Tu, Wenwen Li, Xiantao Kong

Affiliation

¹ Clinical Immunology Center of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

PMID: 12392611

Abstract

Objective: To evaluate the value of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis (PBS).

Methods: M2 autoantibodies were detected by ELISA combined with western-blot.

Results: Thirty-two cases presented positive M2 autoantibodies, including 20 cases of PBC, 9 liver diseases of unknown etiology, 1 autoimmune hepatitis and 1 drug-induced liver injury.

Conclusions: M2 autoantibodies show good sensitivity and specificity to diagnosis of PBC. It should be used as a powerful and specific maker for the diagnosis of PBC

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies / immunology*
Autoantigens / immunology*
Chemical and Drug Induced Liver Injury
Enzyme-Linked Immunosorbent Assay
Hepatitis, Autoimmune
Humans
Liver Cirrhosis, Biliary / diagnosis*
Sensitivity and Specificity

Substances

Autoantibodies
Autoantigens