Chiral C(2)-symmetric ligands with 1,4-dioxane backbone derived from tartrates: syntheses and applications in asymmetric hydrogenation

J Org Chem. 2002 Nov 1;67(22):7618-23. doi: 10.1021/jo020250t.

Abstract

Chiral 1,4-diphenylphosphines 5-7 as well as thioether 8 were synthesized from tartrates employing Ley's "BDA" and "Dispoke" methodologies as the key step. Rhodium(I) complexes with 5-7 are efficient catalysts for the asymmetric hydrogenation of beta-substituted enamides and MOM-protected beta-hydroxyl enamides, which furnished chiral amines or beta-amino alcohols with 94-->99% ee. These results indicated that the 1,4-dioxane backbone in the ligands having the general structure 2 played an important role in stabilizing metal-ligand chelate conformation. Higher enantioselectivities with ligand 2 were achieved compared with the analogous ligands having the general structure 1.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Dioxanes / chemistry*
  • Hydrogenation
  • Ligands
  • Molecular Structure
  • Stereoisomerism
  • Tartrates / chemistry*

Substances

  • Dioxanes
  • Ligands
  • Tartrates
  • 1,4-dioxane
  • tartaric acid