Abstract
Three new diterpenoids, a neoclerodane and two labdane derivatives, have been isolated from an acetone extract of Plectranthus ornatus. The structures of these compounds (plectrornatins A-C, 1-3, respectively) were established mainly by spectroscopic means, particularly by 1D and 2D NMR studies and, in the case of the neoclerodane 1, by an X-ray diffraction analysis. Compounds 1 and 3 showed moderate antimicrobial activity against five Candida species and selected Gram negative and Gram positive bacteria strains.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Candida / drug effects
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Crystallography, X-Ray
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Diterpenes, Clerodane
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Models, Molecular
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Plectranthus / chemistry*
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Spectrometry, Mass, Electrospray Ionization
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Diterpenes
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Diterpenes, Clerodane
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labdane
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neoclerodane