Pre- and postoperative verbal memory in pediatric patients with temporal lobe epilepsy

Epilepsy Res. 2002 Oct;51(3):287-96. doi: 10.1016/s0920-1211(02)00158-4.

Abstract

Outcome studies concerning memory after pediatric temporal lobe surgery in the treatment of epilepsy are rare and have not yielded consistent results. In the present study, 55 children and adolescents with temporal lobe epilepsy (TLE; 26 left, 29 right, 6-17 years) performed a verbal memory test before and 3 as well as 12 months after different types of temporal lobe resections (anterior lobectomy, amygdalo-hippocampectomy (AH), lesionectomy (LX)). Groups did not significantly differ before surgery. Three months after surgery, the left resected group showed a decline in learning and delayed recall, and performed significantly lower than the right resected group. Recoveries were evident 1 year after surgery. The postoperative memory declines were associated with a left-sided resection and a higher preoperative performance. Comparisons on the different resection types suggest a special risk in patients undergoing a left-sided AH. In summary, our results indicate a functional association of verbal memory functions with the left temporal lobe similar to findings in adult patients. Declines after left-sided temporal resections seem to be reversible at least for part of the children, perhaps due to the greater plasticity of the immature brain.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Brain / cytology
  • Brain / physiopathology
  • Brain / surgery
  • Child
  • Epilepsy, Temporal Lobe / physiopathology*
  • Epilepsy, Temporal Lobe / surgery
  • Female
  • Functional Laterality
  • Humans
  • Male
  • Memory / physiology*
  • Neuropsychological Tests
  • Postoperative Complications
  • Postoperative Period
  • Statistics, Nonparametric
  • Time Factors
  • Treatment Outcome
  • Verbal Learning / physiology*